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Curriculum
vitae
Birth Place and Date: Parma, December 17, 1945.
Address: Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy.
Telephone Number: +39 (1139 from USA) 0382-422037
CURRENT POSITION: Director, since 1987.
Title: Professore Ordinario (Full Professor) of Nephrology, since 1986.
University: Faculty of Medicine, Pavia.
Hospital: Policlinico San Matteo, Pavia
PREVIOUS POSITIONS:
1971-1977 (October): Assistant, Dpt. Internal Medicine, University of Parma.
1977-1986 (October): Deputy Director (Aiuto), Unit of Nephrology, University of Naples.
1986-1987 (March): Full Professor (Professore Ordinario) of Nephrology, University of Sassari
1987-1992 (October): Full Professor of Nephrology and Director, Unit of Nephrology, University of Reggio Calabria at Catanzaro.
1992- today: Full Professor of Nephrology, University of Pavia.
1995 (October) Director of Unit of Nephrology Dialysis Transplantation, Policlinico San Matteo, Pavia.
APPOINTMENTS:
1984-87: Council Member, European Dialysis Transplant Association - European Renal Association.
1998-2001: Council Member, Italian Society of Nephrology.
1989-1992: Director, School of Specialization in Nephrology, University of Reggio Calabria at Catanzaro.
1995-today: Director, School of Specialization in Nephrology, University of Pavia.
1995-today: UEMS (Union European Medical Representative) Italian representative, Nephrology Section.
2000-2007: Referee, CME program, Italian Ministero della Salute.
2008-2010: President, Italian Society of Nephrology (Società Italiana di Nefrologia)
2010-today: Dean, University of Pavia School of Medicine
RELEVANT CLINICAL RESEARCH EXPERIENCE
Troughout the career:
- physiology of glomerular hemodynamics (renal micropuncture)
- pathophysiology and therapy of water and salt retention
- pathophysiology and therapy of hypertension
- pathophysiology and therapy of acute and chronic renal failure, including renal replacement therapy with dialysis and transplantation
- growth factors in renal physiology and disease
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MAIN PUBLICATIONS
(impact factor > 3)
Morphologic identification of microperfused-fixed single nephrons during renal micropuncture. Kidney International 5:300-302, 1974
(4,773)
Reliability of radioactive inulin as a marker of glomerular filtration rate in the rat. Pflugers Arch. 1974;350(4):347-58.
(4.807)
Role of efferent arteriole in glomerular hemodynamics. Kidney International 9:475-480, 1976
(4,773)
Effects of acute ureteral obstruction on glomerular hemodynamics in rat kidney. Kidney International 12:403-411, 1977
(4,773)
Effects of 24-hour unilateral ureteral obstruction on glomerular dynamics in rat kidney. Kidney Internatinal 15:457-462, 1979
(4.773)
Glomerular hemodynamics before and after release of 24 hour bilateral ureteral obstruction Kidney International 17:491-496, 1980
(4,773)
Muzolimine: a new high-ceiling diuretic suitable for patients with advanced renal disease. British Medical Journal 282:595-598, 1981
(9.245)
Effects of pregnancy on glomerular dynamics. Micropuncture study in the rat. Kidney International 22:608-612, 1982
(4.773)
Usefulness of hypnosis for carrying out renal needle biopsy in children. Kidney International 26: 351-352, 1984
(4,773)
Mechanism of impaired concentration in chronic primary glomerulonephritis. Kidney International 27:792-798, 1985.
(4.773)
Diuretic therapy in uremic patients. Kidney International 28: 154-156, 1985
(4.773)
Mechanism of increased plasma urea after diuretic therapy in uraemic patients. Clin Sci (Lond). 1985 Mar;68(3):255-61.
(3.263)
Polyuric prerenal failure after reduction from high to normal dietary saline intake. Archives of Internal Medicine 9: 1814-1816, 1986.
(7.92)
Captopril and impaired renal function. Annals of Internal Medicine 104:263, 1986.
(14.78)
Renal handling of urea in subjects with persistent azotemia and normal renal function. Kidney International 32:721-727, 1987.
(4,773)
Percutaneous renal embolization in renovascular hypertension. British Medical Journal 296:1160-1161, 1988
(9.245)
Theory of urine formation and uroscopic diagnosis in the medical school of Salerno. Kidney International 34:273-277, 1988.
(4.773)
Acute cyclosporine dysfunction reversed by dopamine infusion in healthy subjects. Kidney International 36:1086-1092, 1989
(4.773)
Glomerular dynamics and salt balance in pregnant rats with renal hypertension. American Journal of Physiology 256: F728-F734, 1989.
(4.199)
Reversibility of acute cyclosporin nephrotoxicity by dopamine. Micropuncture study in the rat. Nephrol Dial Transplant. 4(5):327-33, 1989.
(3.154)
Acute increase in plasma osmolality as a cause of hyperkalemia in patients with renal disease. Kidney International 38:301-307, 1990
(4.773)
Role of atrial natriuretic factor in renal adaptation to variation of salt intake in humans. American Journal of Physiology 258: 1579-1583, 1990
(4.199)
Absence of acute nephrotoxicity with low doses of cyclosporin: experimental study in the rat. Nephrol Dial Transplant. 5(1):69-74, 1990.
(3.154)
Interleukin-6 production of uraemic haemodialysed patients: effects of different membranes. Nephrol Dial Transplant. 6: Suppl 2:96-8, 1991.
(3.154)
Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis. Kidney International 41:220-224, 1992.
(4.773)
Role of inhibition of atrial natriuretic factor release in the down- regulation of salt excretion. Kidney International 42: 673- 680, 1992.
(4.773)
Hemodialysis related induction of interleukin-6 production by peripheral blood mononuclear cells. Kidney International 42: 320-326, 1992
(4.773)
Extra-natriuretic effects of atrial natriuretic peptide in humans. Kidney International 43: 307- 313, 1993
(4.773)
Prevalence of symptoms in patients with simple renal cysts. British Medical Journal 306: 430-431, 1993.
(9.245)
Interleukin-6 production induced in peripheral blood mononuclear cells by a serum factor from IgA nephropathy patients is inhibited in vitro by specific sugars. Nephrol Dial Transplant. 9(11):1560-3, 1994.
(3.154)
Adhesion molecules in renal disease. Kidney International 48:1687-1696, 1995.
(4,773)
Serial morphometric analysis of sclerotic lesions in primary focal segmental glomerulosclerosis. Journal American Society Nephrology 7:49-55, 1996
(7.371)
Effects of age on the role of atrial natriuretic factor in renal adaptation to physiologic variations of dietary salt intake. Journal American Society Nephrology 7:1045-1051, 1996
(7.371)
Circulating serum lectins of patients with IgA nephropathy stimulate IL-6 release from mesangial cells. Journal American Society Nephrology 8: 208-213, 1997.
(7.371)
Hemodialysis stimulates hepatocyte growth factor release. Kidney International 53: 1382-8, 1998.
(4.773)
Hemodialysis prevents liver disease caused by hepatitis C virus: role of Hepatocyte Growth Factor. Kidney International 56: 2286-2291, 1999.
(4.773)
Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney International 58:123-130, 2000.
(4.773)
Long-term exposure to high glucose up-regulates VCAM-induced endothelial cell adhesiveness to PBMC. Kidney International 59:1842-1849, 2001.
(4.773)
Polarization of T-Helper lymphocytes toward the Th2 phenotype in uremic patients. American Journal Kidney Disease 38:286-295, 2001
(4.072)
Hepatocyte Growth Factor/Scatter Factor released during peritonitis is active on mesothelial cells. American Journal of Pathology 159:1-11, 2001.
(5.917)
Macrophage-Stimulating protein is produced by tubular cells and activates mesangial cells. Journal of the American Society of Nephrology 13:649-657, 2002.
(7.371)
Hypercarotenemia. New England Journal of Medicine 346:821, 2002
(51.296)
Lunch-related polyuria. American Journal of Kidney Disease 40:218-9, 2002.
(4.072)
Correlation between hyperhomocysteinemia and interleukin-18 serum levels in maintenance hemodialyzed patients. - Kidney International 62: 1900, 2002.
(4.773)
Inverse association between homocysteine and vascular endothelial growth factor receptor serum levels in hemodialyzed and kidney transplanted patients. Kidney International 64(5):1922, 2003.
(4.773)
Prevalence of hyperhomocysteinemia in male hemodialysis patients. Kidney International 64:1531, 2003.
(4.773)
Peritoneal dialysis and epithelial-to-mesenchymal transition. New England Journal of Medicine. 348:2037-9, 2003
(51.296)
The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma. American Journal of Surgical Pathology 27:779-85, 2003.
(4.144)
Vitamin E-loaded dialyzer resets PBMC-operated cytokine network in dialysis patients. Kidney International 65:1473-81, 2004
(4.773)
A comparative prospective study of two available solutions for kidney and liver preservation. Transplantation 2004 77: 1540-5, 2004.
(3.972)
Mycophenolate mofetil in IgA nephropathy. Kidney International 66:1713, 2004
(4.773)
Hepatocyte growth factor modulates matrix turnover in human glomeruli. Kidney International. 67:2143-50, 2005.
(4.773)
C-reactive protein and coronary artery disease in hemodialyzed patients. Kidney International 68:1374-5, 2005.
(4.773)
Hepatocyte growth factor and its receptor Met are induced in crescentic glomerulonephritis. Nephrol Dial Transplant. 20(6):1066-74, 2005.
(3.154)
B-type natriuretic peptide dialysis clearance and renal function in patients with decompensated heart failure. American Journal of Kidney Disease 47:562-3, 2006.
(4.072)
Henle loop basement membrane as initial site for randall plaque formation. American Journal of Kidney Disease 48:706-11, 2006.
(4.072)
The effect of sirolimus- or cyclosporine-based immunosuppression effects on T-cell subsets in vivo. Kidney International. 72:114-120, 2007
(4.773)
Neutralization of Macrophage-Stimulating Protein Ameliorates Renal Injury in Anti-Thy 1 Glomerulonephritis. Journal American Society of Nephrology 18:1486-96, 2007
(7.371)
Folic acid for stroke prevention. Lancet. 2007 370(9588):651, 2007
(25.8)
Burnout in health care providers of dialysis service in Northern Italy a multicentre study. Nephrol Dial Transplant 22(8):2283-90, 2007
(3.154)
Prevention of dialysis hypotension episodes using fuzzy logic control system. Nephrol Dial Transplant. 22(5):1420-7, 2007
(3.154)
Risk factors for chronic renal dysfunction in lung transplant recipients. Transplantation 84(12):1701-3, 2007.
(3.972)
Mycophenolate mofetil in primary glomerulopathies. Kidney Int 73(2):154-62. Epub 2007 Nov 7.
(4.773)
Intermittent haemodiafiltration in refractory congestive heart failure: BNP and balance of inflammatory cytokines. Nephrol Dial Transplant. 22(7):2013-9, 2007. (3.154)
Prevention of dialysis hypotension episodes using fuzzy logic control system. Nephrol Dial Transplant. 2007 May;22(5):1420-7
Neutralization of macrophage-stimulating protein ameliorates renal injury in anti-thy 1 glomerulonephritis. J Am Soc Nephrol. 2007 May;18(5):1486-96.
The effect of sirolimus- or cyclosporine-based immunosuppression effects on T-cell subsets in vivo. Kidney Int. 2007 Jul;72(1):114-20.
Burnout in health care providers of dialysis service in Northern Italy--a multicentre study. Nephrol Dial Transplant. 2007 Aug;22(8):2283-90.
Folic acid for stroke prevention. Lancet. 2007 Aug 25;370(9588):651
Mycophenolate mofetil in primary glomerulopathies.
Kidney Int. 2008 Jan;73(2):154-62.
Clinical policies on the management of chronic kidney disease patients in Italy. Nephrol Dial Transplant. 2008 Feb;23(2):621-6.
Risk factors for chronic renal dysfunction in lung transplant recipients. Transplantation. 2007 Dec 27;84(12):1701-3.
KCNA1 and TRPC6 ion channels and NHE1 exchanger operate the biological outcome of HGF/scatter factor in renal tubular cells. Growth Factors. 2007 Dec;25(6):382-91.
Severe symptomatic hyponatremia during sibutramine therapy: a case report. Am J Kidney Dis. 2008 Jul;52(1):137-9.
Scatter Factors in renal disease: Dr. Jeckyll and Mr. Hyde? Cytokine Growth Factor Rev. 2009 Feb;20(1):77-85.
Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy. Kidney Int. 2009 Mar;75(5):536-41
The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth. Growth Factors. 2009 Jun;27(3):173-80
Quiz page August 2009: Respiratory distress 5 years after kidney transplantation. Am J Kidney Dis. 2009 Aug;54(2):A35-7
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med. 2009 Nov 19;361(21):2019-32
Everolimus with very low-exposure cyclosporine a in de novo kidney transplantation: a multicenter, randomized, controlled trial. Transplantation. 2009 Nov 27;88(10):1194-202
Toll-like receptor 4 expression is increased in circulating mononuclear cells of patients with immunoglobulin A nephropathy. Clin Exp Immunol. 2010 Jan;159(1):73-81.
Inosine monophosphate dehydrogenase variability in renal transplant patients on long-term mycophenolate mofetil therapy. Br J Clin Pharmacol. 2010 Jan;69(1):38-50
Revascularization for renal-artery stenosis. N Engl J Med. 2010 Feb 25;362(8):762-3.
Autoimmune response to heat shock protein 60 in haemodialysis patients. J Intern Med. 2010 Apr;267(4):440
Dialysis treatment and regulatory T cells. Nephrol Dial Transplant. 2010 May;25(5):1723-7
Renal Blood Flow Redistribution During Acute Kidney Injury. Am J Kidney Dis. 2010 Jun 26. [Epub ahead of print]
Mesenchymal stromal cells improve renal injury in anti-Thy 1 nephritis by modulating inflammatory cytokines and scatter factors. Clin Sci (Lond). 2010 Jun 28. [Epub ahead of print]
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